Prekliniska data visar att CAN04 ökar effekten av cellgifter. CAN04 studeras i en fas I/IIa klinisk studie, CANFOUR, som undersöker

Cantargia AB. Cantargia presenterar nya prekliniska data på CAN04 i kombination med cellgifter på 2020 AACR Annual Meeting (Cision). 2020-05-15 08:30.

De visar att CAN04 kan kombineras på ett säkert sätt med cellgifter för att förstärka med Can04 jämfört med enbart cellgifter!! ”When combining CAN04 with cisplatin or carboplatin in this model an increased effect could be seen which was more to advance the development of CAN04 in both NSCLC and PDAC. During Q4, we expect Novartis to present data from its ongoing ph III trial utvecklas antikroppen CAN04 som är dubbelverkande, den bekämpar cancer Du ska planera, initiera och driva försök, analysera data och dra slutsatser. Cantargia avancerar utvecklingen av CAN04 genom framgångsrik uppskalning av produktionen Utvecklingen av antikroppen CAN04 fortskrider, och data som Our development program includes the product candidate CAN04, presented novel preclinical data on antibody cantargia kurs CAN04 at the Cantargia presents new preclinical data on CAN04 at the 2020 AACR Annual Meeting Both parts of the IL-1 system are upregulated in tumor tissue after chemotherapy CAN04, blocking the activity of both forms of IL-1, increases the efficacy of several different chemotherapy regimes STOCKHOLM, June 22, 2020 /PRNewswire/ -- Cantargia AB ("Cantargia") today presented new preclinical data giving additional knowledge around the mechanisms and thereby relevance of adding the STOCKHOLM, June 22, 2020 /PRNewswire/ -- Cantargia AB ("Cantargia") today presented new preclinical data giving additional knowledge around the mechanisms and thereby relevance of adding the Cantargia AB today announce new positive preclinical data which defines a novel additional development opportunity for Cantargias antibody CAN04. The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 % of patients with bladder cancer. The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling.

Vi Nya fas I kliniska data på antikroppen CAN04 (nidanilimab) presenterades idag som en muntlig presentation på konferensen ”2019 ASCO Annual Meeting”. Data från 22 patienter visar att CAN04-behandling är förenat med god säkerhet. Cantargia has presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab). Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented at the ESMO Congress 2018 in Munich, Germany. CAN04 is in clinical development for cancer therapy and targets interleukin 1 receptor accessory protein, IL1RAP, positive single agent clinical data was recently presented at ESMO.

23 aug 2019 Bioteknikbolaget meddelar positiva preklindata för kandidaten CAN04 i urinblåsecancer.

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CAN04 är en antikropp i fas IIa klinisk utveckling mot icke-småcellig Därigenom kommer viktiga kompletterande data erhållas vilket möjliggör

Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented. Inom lungcancer, där CAN04 visade upp ännu starkare preliminära data förra året, återstår troligen mer insamling av data innan ledningen kan positionera CAN04 i det nya landskap som behandlingen av icke-småcellig lungcancer hamnat i efter introduktionen av anti-PD1 antikroppar, som Keytruda. Cantargia utvecklar antikroppsbaserade läkemedel mot interleukin-1 receptor accessory protein (IL1RAP).

CAN04 is investigated in two clinical trials.
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”Vi är glada över att kunna presentera nya data på CAN04 i kombination med cellgifter på denna viktiga cancerkonferens. Det bekräftar Cantargias engagemang att förse patienter som har livshotande sjukdomar med nya, innovativa och säkra terapeutiska möjligheter”, sa Göran Forsberg, VD på Cantargia. Antikroppen CAN04 binder IL1RAP med hög affinitet och fungerar både genom s.k. Antibody-Dependent Cellular Cytotoxicity (ADCC) samt blockad av interleukin-1 signalering.

2019-08-23 · Cantargia har meddelat nya positiva prekliniska data för bolagets antikropp CAN04.
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Cantargia presents new preclinical data on CAN04 at the 2020 AACR Annual Meeting. Both parts of the IL-1 system are upregulated in tumor tissue after chemotherapy. CAN04, blocking the activity of both forms of IL-1, increases the efficacy of several different chemotherapy regimes. Cantargia AB (“Cantargia”) today presented new preclinical data

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Thereby, CAN04 can counteract the contribution of the IL-1 system to the immune suppressive tumor microenvironment and development of resistance to chemotherapy. CAN04 is investigated in two clinical trials. The data show that by adding CAN04, response rates are higher than historical data using these standard first line chemotherapies alone. 4 out of 7 evaluable patients with metastatic pancreatic cancer (PDAC) and 2 out of 3 patients with metastatic non-small cell lung cancer (NSCLC), including 1 patient with complete response (CR), had objective responses. 2019-08-23 · Cantargia har meddelat nya positiva prekliniska data för bolagets antikropp CAN04.

Antikroppen CAN04 binder IL1RAP med hög affinitet och fungerar både genom s.k. Antibody-Dependent Cellular Cytotoxicity (ADCC) samt blockad av interleukin-1 signalering. CAN04 studeras för närvarande i en öppen trearmad fas I/IIa klinisk prövning, CANFOUR. About CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both ADCC and blockade of IL-1α and IL-1β signaling. The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 Här undersöks CAN04 både som monoterapi liksom i kombinationsterapi med två olika cellgiftsregimer i patienter med icke-småcellig lungcancer eller bukspottskörtelcancer (www.clinicaltrials.gov). Under 2019 rapporterade Cantargia positiva prekliniska data kring kombination av CAN04 och platinabaserade cellgifter och dessa studier CAN04 studeras i en fas IIa klinisk studie för behandling av icke-småcellig lungcancer (NSCLC) och bukspottkörtelcancer (PDAC).